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Grapefruit, a widely consumed citrus fruit, contains a primary bioflavonoid called naringin. Naringin's bitterness causes some people to sprinkle sugar on grapefruit sections. According to "Natural Products: A Laboratory Guide" by Raphael Ikan, naringin's bitterness substantially exceeds that of bioflavonoids found in lemons and oranges. Bioflavonoids like naringin are part of vitamin P.
Most people eat citrus fruit like grapefruits or take naringin supplements to quash free radicals in the body. According to the "Doctor's Guide to Natural Medicine" by Paul Barney, naringin and other bioflavonoids "significantly" outperform other antioxidants.
There are many reasons for you to consume more naringin:
Citrus bioflavonoids may block the formation of cancer-causing molecules, according to Dr. Richard Beliveau in Canada. Beth Israel Deaconess Medical Center recaps many ways naringin may benefit health in recent medical research studies. The site says that bioflavonoids like naringin have been used in Europe to treat blood vessel and lymphatic system disease in Europe for many years.
That's why breast cancer patients may benefit from naringin and other bioflavonoids after surgery. The bioflavonoids may help to reduce swelling and reduce fluid collection. Importantly, breast cancer patients taking tamoxifen shouldn't use bioflavonoids without doctor approval. Supplements containing tangeretin are contraindicated for tamoxifen-users.
People with high cholesterol, high blood pressure, hemorrhoids, allergies and other conditions may benefit from naringin supplements, according to recent Beth Israel Deaconess research studies. The Journal of Science of Food and Agriculture also reports that studies suggest narigin may help reduce blood fats and high cholesterol.
Other people use naringin as part of a diabetes-management program. According to "There Is a Cure for Diabetes: The Tree of Life 21+ Day Plan" by Gabriel Cousens and David Rainoshek, narigin, quercetin and hesperidin help to avoid cataracts in diabetic patients. Research published by PubMed also reports possible benefits of naringin supplementation for diabetic people. Eating grapefruit and consuming naringin may help you lose weight, according to research published by the National Institutes of Health.
Discuss how often you eat citrus fruits like grapefruits with your doctor. Naringin’s ability to affect how your body uses some drugs is well-documented. According to previous research published by the National Institutes of Health, how your body metabolizes naringin affects the absorption or blockage of other drugs you take.
According to the Human Metabolome Database, naringin inhibits cytochrome 450 enzymes along with CYP3A4 and CYP1A2. Cytochrome 450 enzymes work in the catalyzing oxidation of organic molecules like steroids and blood fats, toxic chemicals and drugs.
For this reason, naringin’s potential to interact with prescription drugs or other supplements should be discussed with your doctor. The following drugs are known to interact with CYP3A4: sertraline (Zoloft), ritonavir (Norvir), benzodiazepines, triazolam (Halcyon), alprazolam (such as Xanax) and others.
Studies of naringin conclude that it inhibits the body's ability to use some beta blockers, such as talinolol. Other studies show that narinigin decreases the body's ability to use fexofenadine, an antihistamine drug, according to "Drug Transporters" by Martin F. Fromm and Richard B. Kim in 2010.
Use care when consuming grapefruit or naringin supplements if herbs and other supplements form part of your daily regimen, according to “Meyler’s Side Effects of Herbal Medicines” by Jeffrey K. Aronson. The author says that six to eight glasses of grapefruit juice a day, or the equivalent amount of naringin supplements, may interact with CYP3A enzymes.
Other than potential drug interactions cited above, taking naringin is generally considered safe in reasonable amounts. Side effects from consuming grapefruits and grapefruit juice in excessive amounts may cause mild stomach upset or loose stool.
If you’re taking prescription drugs or other supplements, ask your doctor about the best dosage of naringin for you. Some supplements, like St. John’s Wort, also affect the cytochrome P450 enzymes.
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